Peptide Database

Peptide NameEK1C4

Function Ontology

Anticancer

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length41 amino acids

Chemical FormulaC208H336N48O71S

DescriptionStandard

        SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG
    

Molecular Weight4677.24 Da

Isoelectric Point (pI)4.36

Net Charge (pH 7.0)-5.52

Net Charge (pH 7.4) -5.76

Charge Density (pH 7.0) -0.1347

GRAVY Index-0.45

Hydrophobic Moment 0.75

Boman Index-0.02

Instability Index21.17

Aliphatic Index 104.63

Aromaticity 0.0732

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1958.21

LogP -15.67

H-bond Donors 66.0

H-bond Acceptors 67.0

Rotatable Bonds 168.0

Heavy Atoms 328.0

Ring Count 3.0

Amide Bonds 42.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0231027 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermPEG4-Chol

Other ModsPEG4-Chol

Bio-Activity Profile

Function

Antiviral Anti-HCoV-229E Fusion inhibition

TargetHCoV-229E | Huh-7 cells

Activity0.0124 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. | Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L. | Cell Res. 2020 Apr;30(4):343-355. | DOI:10.1038/s41422-020-0305-x | PMID:32231345 PMID32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32231345/

RECORD: Rec_0232487 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermPEG4-25-HC

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

RECORD: Rec_0235277 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermPEG4-Chol

Other ModsPEG4-Chol

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV Fusion inhibition

TargetSARS-CoV | 293T/ACE2 cells

Activity0.0117 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. | Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L. | Cell Res. 2020 Apr;30(4):343-355. | DOI:10.1038/s41422-020-0305-x | PMID:32231345 PMID32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32231345/

RECORD: Rec_0235520 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermPEG4-Chol

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

Targetinhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells

Activity0.0117 μM

MethodIC50

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/

RECORD: Rec_0241219 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermPEG4-Chol

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

TargetSARS-CoV-2 D614G:inhibition of cell-cell fusion

Activity0.00257 μM

MethodIC50

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/

FIRST PREV 1 ... 21 22 23 24 25 ... 36 NEXT LAST

Showing 5 records · Page 23 of 36