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MYP_016060
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Basic Information
Endothelin-3
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
21 amino acids
C121H172N26O33S4
Standard
Sequence
CTCFTYKDKECVYYCHLDIIW
Physicochemical Analysis
2647.07 Da
5.38
-1.19
-1.51
-0.0568
0.10
0.26
0.13
56.15
69.52
0.2381
9970.00
10220.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
954.88
-3.78
38.0
37.0
81.0
184.0
7.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0082147 VERIFIED: NO
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Endothelin
9615
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Myotropic Receptor modulation ACE inhibitory
Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
RECORD: Rec_0125486 VERIFIED: NO
Provenance & Taxonomy
Rattus norvegicus [Animal]
Endothelin/sarafotoxin
10116
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Vasoactive Hormone
Evidence URLhttps://www.uniprot.org/uniprotkb/EDN3_RAT/entry
RECORD: Rec_0148825 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0205567 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Endothelin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Growth regulation Development regulation Myotropic Receptor modulation Immunomodulatory ACE inhibitory
Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
RECORD: Rec_0223139 VERIFIED: NO
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Endothelin
9986
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
1-15; 3-11
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor
Mammalian: 1.2 hour; Yeast: >20 hour; E. coli: >10 hour
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