Peptide Database

Peptide NameRev (34-50) -A4C-RTD

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC176H314N88O42S

DescriptionStandard

        TRQARRNRRRRWRERQRAAAACYGRKKRRQRRR
    

Molecular Weight4367.01 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)16.39

Net Charge (pH 7.4) 16.18

Charge Density (pH 7.0) 0.4966

GRAVY Index-2.70

Hydrophobic Moment 0.49

Boman Index-1.29

Instability Index190.43

Aliphatic Index 15.15

Aromaticity 0.0606

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2302.87

LogP -30.37

H-bond Donors 93.0

H-bond Acceptors 60.0

Rotatable Bonds 157.0

Heavy Atoms 307.0

Ring Count 3.0

Amide Bonds 36.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0393184 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 IIIB | PM1-CCR5 cells

Activity0.37±0.09 μM

MethodEC50

Half-LifeMammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h

PaperRev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4. | Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M. | Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8. | DOI:10.1016/j.biocel.2010.05.005 | PMID:20580677 PMID20580677 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580677/

RECORD: Rec_0397557 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 Bal:inhibition of virus replication in PM1-CCR5 cells

Activity10 μM

MethodEC50

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