Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length286 amino acids

Chemical FormulaC1460H2273N363O407S12

DescriptionStandard

        MENVCEKVTNSVSSELQPYFQTLPVMTKIDAVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAILPNSSLASLFLIGMHTTGSMEVSAESDRLVGELKLDRLLLELKHSNIGPFPVALLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK
    

Molecular Weight31807.63 Da

Isoelectric Point (pI)6.06

Net Charge (pH 7.0)-3.78

Net Charge (pH 7.4) -4.49

Charge Density (pH 7.0) -0.0132

GRAVY Index0.08

Hydrophobic Moment 0.66

Boman Index0.16

Instability Index40.44

Aliphatic Index 95.73

Aromaticity 0.0979

Extinction Coeff. Reduced 14900.00

Extinction Coeff. Oxidized 14900.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0096437 VERIFIED: NO

Provenance & Taxonomy

OrganismPan paniscus [Animal]

FamilyBPI

Tax ID9597

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence