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MYP_015975
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Basic Information
Compound 9048
Antimicrobial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Amylase inhibition ▸ Alpha-amylase inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Glycosidase inhibition ▸ Alpha-glucosidase inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
2 amino acids
C18H20N2O4
Standard
Sequence
FY
Physicochemical Analysis
328.36 Da
5.52
-0.24
-0.45
-0.1205
0.75
0.59
0.72
168.00
0.00
1.0000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
112.65
1.07
4.0
4.0
7.0
24.0
2.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003698 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
4-Methylpiperazinyl carbonyl
Aldehyde
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum W2
0.033 μM
IC50; Flourimetry (Hydrolysis of the fluorogenic substrate)
PMID14638488 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14638488/
RECORD: Rec_0011231 VERIFIED: NO
Provenance & Taxonomy
Allium sativum [Plant]
ACE-inhibitory peptide
4682
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive Antioxidant
Spontaneously hypertensive rat (SHR)
27 mmHg
SBP decrease
PaperVegetable foods: A cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities. PMID23598136 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23598136/
RECORD: Rec_0030755 VERIFIED: YES
Provenance & Taxonomy
Allium sativum [Plant]; Perilla frutescens [Plant]
ACE inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive Antioxidant Enzyme inhibitory
Angiotensin-converting enzyme
42.3 μM
IC50
PaperAngiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats | Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats | Isolation from alpha-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity | Isolation and characterization of peptides with antihypertensive activity in foodstuffs | Vegetable foods: a cheap source of proteins and peptides with antihypertensive, antioxidant, and other less occurrence bioactivities | Bioactive peptides in amaranth (Amaranthus hypochondriacus) seed | PubMed PMID 29985955 | PubMed PMID 22249830 | PubMed PMID 1368684 PMID29985955;22249830;1368684;12358510;151351;50000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29985955/
RECORD: Rec_0031121 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic Alpha-glucosidase inhibitory
Alpha-glucosidase
PaperAl-Bukhaiti W. Q., Al-Dalali S., Li H., Yao L., Abed S. M., Zhao L., Qiu S.-X.. Identification and in vitro characterization of novel antidiabetic peptides released enzymatically from peanut protein. Plant Foods Hum. Nutr., 79, 66-72, 2024.
RECORD: Rec_0034103 VERIFIED: NO
Provenance & Taxonomy
Apis mellifera [Animal]
ACE-inhibitory peptide
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
1.67-930 μM
IC50
PaperISOLATION AND CHARACTERIZATION OF PEPTIDES WITH ANTIHYPERTENSIVE ACTIVITY IN FOODSTUFFS. PMID24915368 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24915368/
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