MYP_015944
Microbisporicin A1
Antimicrobial
Antimicrobial
▸
Antibacterial
Antimicrobial
▸
Antibacterial
▸
Anti-Gram-positive
Antimicrobial
▸
Antibiotic activity
Immunology
▸
Innate immune defense
▸
Host defense peptide
▸
Host defense activity
Toxicity / Safety
▸
Negative safety assay result
▸
Non-hemolytic
Standard
24 amino acids
C95H144N26O34S5
Standard
VTSWSLCTPGCTSPGGGSNCSFCC
2354.64 Da
5.47
-0.32
-0.60
-0.0131
0.33
0.13
0.25
60.60
28.33
0.0833
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
935.76
-16.62
38.0
39.0
67.0
160.0
5.0
24.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0411586
VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial
Antibacterial
Moraxella catarrhalis ATCC8176
0.25 μg/mL
MIC
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