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MYP_015944
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Basic Information
Microbisporicin A1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C95H144N26O34S5
Standard
Sequence
VTSWSLCTPGCTSPGGGSNCSFCC
Physicochemical Analysis
2354.64 Da
5.47
-0.32
-0.60
-0.0131
0.33
0.13
0.25
60.60
28.33
0.0833
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
935.76
-16.62
38.0
39.0
67.0
160.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0343171 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Propionibacterium limphophylum ATCC27250
0.015 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
RECORD: Rec_0345869 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus haemolyticus met-r
8 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
RECORD: Rec_0354774 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecium
2 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
RECORD: Rec_0390111 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus VISA
2 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
RECORD: Rec_0396189 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Streptococcus pneumoniae
0.13 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
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