‹ ›
MYP_015944
← PREVIOUS NEXT → BACK
Basic Information
Microbisporicin A1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C95H144N26O34S5
Standard
Sequence
VTSWSLCTPGCTSPGGGSNCSFCC
Physicochemical Analysis
2354.64 Da
5.47
-0.32
-0.60
-0.0131
0.33
0.13
0.25
60.60
28.33
0.0833
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
935.76
-16.62
38.0
39.0
67.0
160.0
5.0
24.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0277157 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Clostridium butyricum
0.125 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
RECORD: Rec_0304443 VERIFIED: YES
Provenance & Taxonomy
Microbispora sp. [Bacterium]
Lantibiotic
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic
Gram Positive Bacteria
PaperPDB:2MH5
RECORD: Rec_0318384 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Haemophilus influenzae ATCC19418
32 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
RECORD: Rec_0327803 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis Van A
1 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
RECORD: Rec_0329273 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis Van A
0.5 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
FIRST PREV 1 ... 4 5 6 7 8 NEXT LAST
Showing 5 records on this page · Page 6 of 8