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MYP_015944
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Basic Information
Microbisporicin A1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C95H144N26O34S5
Standard
Sequence
VTSWSLCTPGCTSPGGGSNCSFCC
Physicochemical Analysis
2354.64 Da
5.47
-0.32
-0.60
-0.0131
0.33
0.13
0.25
60.60
28.33
0.0833
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
935.76
-16.62
38.0
39.0
67.0
160.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0202659 VERIFIED: YES
Provenance & Taxonomy
Microbispora sp. [Bacterium]
type A lantibiotic family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-Thr: (E)-2,3-didehydrobutyrine; 4-Trp: 6'-chlorotryptophan; 5-Ser: 2,3-didehydroalanine (Ser); 14-Pro: 3,4-dihydroxyproline; in form A1; 14-Pro: 4-hydroxyproline; in form A2
Bio-Activity Profile
Antimicrobial type A lantibiotic family Antibacterial Host defense
PaperPDB 2MH5 structural record; NMR; chain A; residues 1-23
RECORD: Rec_0202665 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0204480 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Neisseria gonorrhoeae
0.25 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
RECORD: Rec_0257918 VERIFIED: NO
Provenance & Taxonomy
Microbispora sp. [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 2023/0416797 A1 Evidence URLhttps://patents.google.com/patent/US20230416797A1/en PatentUS 2023/0416797 A1
RECORD: Rec_0260479 VERIFIED: YES
Provenance & Taxonomy
Microbispora corallina [Bacterium]
Bacteriocin
Structure & Mods
thioether-bridged cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline
Bio-Activity Profile
Antimicrobial Antibacterial
Streptococcus pyogenes
0.13 μg/mL
MIC
PMID18215770 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18215770/
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