Peptide Database

Peptide NameMicrobisporicin A1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC95H144N26O34S5

DescriptionStandard

        VTSWSLCTPGCTSPGGGSNCSFCC
    

Molecular Weight2354.64 Da

Isoelectric Point (pI)5.47

Net Charge (pH 7.0)-0.32

Net Charge (pH 7.4) -0.60

Charge Density (pH 7.0) -0.0131

GRAVY Index0.33

Hydrophobic Moment 0.13

Boman Index0.25

Instability Index60.60

Aliphatic Index 28.33

Aromaticity 0.0833

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5750.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 935.76

LogP -16.62

H-bond Donors 38.0

H-bond Acceptors 39.0

Rotatable Bonds 67.0

Heavy Atoms 160.0

Ring Count 5.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0108073 VERIFIED: YES

Provenance & Taxonomy

OrganismMicrobispora corallina [Bacterium]

FamilyBacteriocin

Structure & Mods

Configthioether-bridged cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation; Cyclization

Other Mods①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetClostridium difficile

Activity0.125 μg/mL

MethodMIC

RECORD: Rec_0112850 VERIFIED: YES

Provenance & Taxonomy

OrganismMicrobispora corallina [Bacterium]

FamilyBacteriocin

Structure & Mods

Configthioether-bridged cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation; Cyclization

Other Mods①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetClostridium perfringens ATCC13124

Activity0.125 μg/mL

MethodMIC

RECORD: Rec_0117188 VERIFIED: YES

Provenance & Taxonomy

OrganismMicrobispora corallina [Bacterium]

FamilyBacteriocin

Structure & Mods

Configthioether-bridged cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation; Cyclization

Other Mods①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetLactobacillus delbrueckii ATCC04797

Activity4 μg/mL

MethodMIC

RECORD: Rec_0117499 VERIFIED: YES

Provenance & Taxonomy

OrganismMicrobispora corallina [Bacterium]

FamilyBacteriocin

Structure & Mods

Configthioether-bridged cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation; Cyclization

Other Mods①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEnterococcus faecium Van A

Activity2 μg/mL

MethodMIC

RECORD: Rec_0138372 VERIFIED: YES

Provenance & Taxonomy

OrganismMicrobispora corallina [Bacterium]

FamilyBacteriocin

Structure & Mods

Configthioether-bridged cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation; Cyclization

Other Mods①There are five thioether intramolecular bridges which link Ala3 and Ala7, Ala8 and Ala11, Ala13 and Ala20, Ala18 and Ala23, respectively. ②The residue at position 2 is (Z)-2,3-didehydrobutyrine (Dhb). ③The residue at position 4 is chloro-tryptophan (ClTrp). ④The residue at position 5 is 2,3-didehydroalanine. ⑤The residue at position 8 is 2-Aminobutyric acid (Abu). ⑥The residue at position 14 is bis-hydroxylated proline

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEnterococcus faecium Van A

Activity1 μg/mL

MethodMIC

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