Peptide Database

Peptide NamePorcine big endothelin-1 (Porcine big-ET-1)

Function Ontology

Vasoconstricting peptide

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC192H296N50O58S5

DescriptionStandard

        CSCSSLMDKECVYFCHLDIIWVNTPERVVPYGLGSPSRS
    

Molecular Weight4393.03 Da

Isoelectric Point (pI)5.48

Net Charge (pH 7.0)-1.19

Net Charge (pH 7.4) -1.51

Charge Density (pH 7.0) -0.0304

GRAVY Index0.09

Hydrophobic Moment 0.52

Boman Index0.10

Instability Index71.90

Aliphatic Index 79.74

Aromaticity 0.1026

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1711.40

LogP -16.70

H-bond Donors 64.0

H-bond Acceptors 63.0

Rotatable Bonds 136.0

Heavy Atoms 305.0

Ring Count 9.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0402003 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyEndothelin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Vasoconstricting peptide

MethodRadioimmunoassay and RP-HPLC

Half-LifePurified ET-1 protein sample, in vitro; 1500 s