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MYP_015898
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Basic Information
LL-37 (17-29) [R23L]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C80H134N22O17
Standard
Sequence
FKRIVQLIKDFLR
Physicochemical Analysis
1676.06 Da
11.00
2.76
2.55
0.2122
0.20
0.94
-0.11
18.70
142.31
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
668.75
-1.93
24.0
20.0
59.0
119.0
2.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0050217 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
114 μg/mL
HC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0169742 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
18.9 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0229324 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
18.9 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0268237 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
227 μg/mL
HC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
RECORD: Rec_0337515 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: A549
13.9 μg/mL
IC50
PaperCationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. J Pept Sci. 2020;26:e3254. doi: 10.1002/psc.3254. PMID: 32567085. PMID32567085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32567085/
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