Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length513 amino acids

Chemical FormulaC2599H4059N653O744S20

DescriptionStandard

        MLPLLEMRTKAVQVLWGCFFLWSLHISSAQTIYPGIKARVTQRALDYGVLAGMDMIEQMVKERKIPDLRGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEIRSPLFQDTGGADLFLSGVYFTGIIVLARNGFGHPILKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIMSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYMELNLKGVFYPLDNLTDPPFSPVPFVLPERSDSMLYVGISEFFFKSASFAYFTAGAFNVTLSMKEISNHLVQNSQGLGNVLSRIAEIYILSQPFMVRVMATEPPVISLQPGNFTLDIPASIVLLAQTENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESNRSNIEVLRFENVLSSILHFGILPLANAKLQQGIPLPNPRKISFVNSDIEVFEGFLLISTDLKYEMSLKQQPSFHGWEGLNLISGQWRGKPAA
    

Molecular Weight56998.26 Da

Isoelectric Point (pI)5.32

Net Charge (pH 7.0)-10.77

Net Charge (pH 7.4) -11.56

Charge Density (pH 7.0) -0.0210

GRAVY Index0.20

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index38.84

Aliphatic Index 104.70

Aromaticity 0.1014

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50100.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0071243 VERIFIED: NO

Provenance & Taxonomy

OrganismUrsus arctos horribilis [Bacterium]

FamilyBPI

Tax ID116960

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence