‹ ›
MYP_015734
← PREVIOUS NEXT → BACK
Basic Information
Psyle E
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C139H227N37O42S6
Standard
Sequence
GVIPCGESCVFIPCISSVLGCSCKNKVCYRD
Physicochemical Analysis
3280.90 Da
7.77
0.70
0.41
0.0227
0.65
0.35
0.18
30.99
87.74
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1251.52
-13.87
49.0
49.0
104.0
224.0
4.0
31.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0009298 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
This is the longest cyclotide in this cyclotide series. Anticancer assay: human lymphoma cell line U937-GTB
0.76 μM
IC50
PaperIsolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa.
RECORD: Rec_0013107 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic
MCF-7/ADR
1.73 μM
IC50
PaperPubMed PMID 20564026 | PubMed PMID 20575510 PMID20564026;20575510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564026/
RECORD: Rec_0044499 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic
MCF-7
0.64 μM
IC50
PaperPubMed PMID 20564026 | PubMed PMID 20575510 PMID20564026;20575510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564026/
RECORD: Rec_0066277 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Animal]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Anticancer Cytotoxic
PaperPubMed PMID: 20575512 PMID20575512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20575512/
RECORD: Rec_0095917 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
Lymphoma cell line
0.76 μM
IC50
1 2 3 4 NEXT LAST
Showing 5 records on this page · Page 1 of 4