Peptide Database

Peptide NameRANATUERIN 2P

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Antiviral ▸ Virucidal activity

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC128H225N37O37S4

DescriptionStandard

        GLMDTVKNVAKNLAGHMLDKLKCKITGC
    

Molecular Weight3002.64 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)2.82

Net Charge (pH 7.4) 2.53

Charge Density (pH 7.0) 0.1009

GRAVY Index0.04

Hydrophobic Moment 0.65

Boman Index0.03

Instability Index-11.91

Aliphatic Index 97.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1209.04

LogP -11.60

H-bond Donors 43.0

H-bond Acceptors 45.0

Rotatable Bonds 107.0

Heavy Atoms 206.0

Ring Count 1.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0312623 VERIFIED: YES

Provenance & Taxonomy

OrganismAnura [Animal]

FamilyRanatuerin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Virucidal

TargetFrog virus 3 (Virucidal); FHM

Activity80 %

MethodPlaque assay

PaperInactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. | Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L. | Virology. 2001 | PMID:11601906 PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/

RECORD: Rec_0364105 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Anticancer

RECORD: Rec_0364865 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates pipiens [Animal]

FamilyRanatuerin

Tax ID8404

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization of a C-terminal Cys residue (forming a disulfide bond)

Disulfide22-27

Other ModsThere is a disulfide bond between Cys22 and Cys27.; Cyclization of a C-terminal Cys residue (forming a disulfide bond)

Bio-Activity Profile

Function

Antiviral Anti-CCV Entry inhibition

TargetChannel Catfish virus (CCV)

Activity50 μM

Method% inhibition

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperInactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. | Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L. | Virology. 2001 Sep 30;288(2):351-7. | DOI:10.1006/viro.2001.1080 | PMID:11601906 PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/

RECORD: Rec_0371588 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates pipiens [Animal]

FamilyRanatuerin

Structure & Mods

ConfigLinear peptide with a single intramolecular disulfide-stabilized loop [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

Disulfide23-28

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetEscherichia coli

Activity13.0 μM

MethodMIC

PaperJ. Goraya et al. / Eur. J. Biochem. 267 (2000) 894-900. Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/

RECORD: Rec_0385361 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates pipiens [Animal]

Tax ID8404

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetT cells

Activity35 %

MethodInhibition

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