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MYP_015683
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Basic Information
RANATUERIN 2P
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Antiviral ▸ Virucidal activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Standard
28 amino acids
C128H225N37O37S4
Standard
Sequence
GLMDTVKNVAKNLAGHMLDKLKCKITGC
Physicochemical Analysis
3002.64 Da
9.24
2.82
2.53
0.1009
0.04
0.65
0.03
-11.91
97.50
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1209.04
-11.60
43.0
45.0
107.0
206.0
1.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0180259 VERIFIED: YES
Provenance & Taxonomy
Anura [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal
Channel catfish virus (Virucidal); CCO
40 %
Plaque assay
PaperInactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. | Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L. | Virology. 2001 | PMID:11601906 PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0202384 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
Ranatuerin
8404
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization of a C-terminal Cys residue (forming a disulfide bond)
22-27
There is a disulfide bond between Cys22 and Cys27.; Cyclization of a C-terminal Cys residue (forming a disulfide bond)
Bio-Activity Profile
Antiviral Anti-FV3 Entry inhibition
Frog Virus 3 (FV3)
500 μM
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. | Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L. | Virology. 2001 Sep 30;288(2):351-7. | DOI:10.1006/viro.2001.1080 | PMID:11601906 PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0212352 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Ranatuerin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
22-27
Bio-Activity Profile
Antimicrobial Antiviral
Channel Catfish virus(CCV)
PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0216371 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-28
Bio-Activity Profile
Antimicrobial Antifungal
PaperJ. Goraya et al. / Eur. J. Biochem. 267 (2000) 894-900. Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0301916 VERIFIED: YES
Provenance & Taxonomy
American frog [Animal]
Ranatuerin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-28
Bio-Activity Profile
Antimicrobial
PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
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