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MYP_015660
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Basic Information
Buforin-1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
39 amino acids
C184H318N70O47
Standard
Sequence
AGRGKQGGKVRAKAKTRSSRAGLQFPVGRVHRLLRKGNY
Physicochemical Analysis
4262.93 Da
12.00
11.88
11.63
0.3045
-0.99
0.83
-0.38
46.12
62.56
0.0513
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1962.60
-24.65
73.0
60.0
150.0
301.0
4.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0249570 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Streptococcus mutans
8 μg/mL
MIC
PMID8573171 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
RECORD: Rec_0249812 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
①The residue at position 5 is N6-(2-hydroxyisobutyryl)lysine or N6-acetyllysine. ②The residue at position 9 is N6-(2-hydroxyisobutyryl)lysine or N6-lactoyllysine or N6-succinyllysine. ③The Lys13 has a interchain with G-Cter in ubiquitin. ④The Lys15 has a interchain with G-Cter in ubiquitin. ⑤The residue at position 36 is N6-(2-hydroxyisobutyryl)lysine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
8 μg/mL
MIC
PMID8573171;8946958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
RECORD: Rec_0267712 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
①The residue at position 5 is N6-(2-hydroxyisobutyryl)lysine or N6-acetyllysine. ②The residue at position 9 is N6-(2-hydroxyisobutyryl)lysine or N6-lactoyllysine or N6-succinyllysine. ③The Lys13 has a interchain with G-Cter in ubiquitin. ④The Lys15 has a interchain with G-Cter in ubiquitin. ⑤The residue at position 36 is N6-(2-hydroxyisobutyryl)lysine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas putida
4 μg/mL
MIC
PMID8573171;8946958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
RECORD: Rec_0272977 VERIFIED: YES
Provenance & Taxonomy
Bufo gargarizans [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
①The residue at position 5 is N6-(2-hydroxyisobutyryl)lysine or N6-acetyllysine. ②The residue at position 9 is N6-(2-hydroxyisobutyryl)lysine or N6-lactoyllysine or N6-succinyllysine. ③The Lys13 has a interchain with G-Cter in ubiquitin. ④The Lys15 has a interchain with G-Cter in ubiquitin. ⑤The residue at position 36 is N6-(2-hydroxyisobutyryl)lysine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Streptococcus mutans
8 μg/mL
MIC
PMID8573171;8946958 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8573171/
RECORD: Rec_0280736 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Buforin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans, Cryptococcus neoformans, and Saccharomyces cerevisiae
4 μg/mL
MIC
PaperA novel antimicrobial peptide from Bufo bufo gargarizans.
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