Peptide Database

Peptide NameKaliotoxin 3

Function Ontology

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC166H281N53O47S8

DescriptionStandard

        VGIPVSCKHSGQCIKPCKDAGMRFGKCMNRKCDCTPK
    

Molecular Weight4027.85 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)5.76

Net Charge (pH 7.4) 5.40

Charge Density (pH 7.0) 0.1556

GRAVY Index-0.47

Hydrophobic Moment 0.72

Boman Index-0.17

Instability Index28.46

Aliphatic Index 39.46

Aromaticity 0.0270

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1614.62

LogP -19.63

H-bond Donors 61.0

H-bond Acceptors 62.0

Rotatable Bonds 136.0

Heavy Atoms 274.0

Ring Count 5.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0169639 VERIFIED: YES

Provenance & Taxonomy

OrganismButhus occitanus tunetanus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide3 disulfide bonds reported, sites unresolved

Bio-Activity Profile

Function

Potassium channel inhibitor Neurotoxin Toxin

TargetKTX-sensitive potassium-channel binding sites on rat brain synaptosomes

Activity50 pM

Method[125I]-KTX competitive binding (IC50)