Peptide Database

Peptide NameBradykinin-potentiating peptide 4

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Membrane / Ion-channel modulation ▸ Ion channel modulation

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC68H100N20O14

DescriptionStandard

        QKKWPPGHHIPP
    

Molecular Weight1421.65 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)1.93

Net Charge (pH 7.4) 1.63

Charge Density (pH 7.0) 0.1610

GRAVY Index-1.74

Hydrophobic Moment 0.22

Boman Index-0.12

Instability Index75.48

Aliphatic Index 32.50

Aromaticity 0.0833

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 516.54

LogP -2.39

H-bond Donors 15.0

H-bond Acceptors 18.0

Rotatable Bonds 38.0

Heavy Atoms 102.0

Ring Count 8.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0319522 VERIFIED: YES

Provenance & Taxonomy

OrganismLachesis muta muta [Animal]

FamilyBradykinin-potentiating peptide

Tax ID8753

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Enzyme modulation Ion channel modulation ACE inhibitory

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0427147 VERIFIED: YES