Peptide Database

Peptide NameSLAY-screened peptide P5280

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC104H161N33O33S2

DescriptionStandard

        YSPVHTTSGRMCININDWRTN
    

Molecular Weight2465.72 Da

Isoelectric Point (pI)8.23

Net Charge (pH 7.0)0.84

Net Charge (pH 7.4) 0.57

Charge Density (pH 7.0) 0.0399

GRAVY Index-0.79

Hydrophobic Moment 0.39

Boman Index-0.13

Instability Index49.80

Aliphatic Index 50.95

Aromaticity 0.0952

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1092.75

LogP -13.94

H-bond Donors 40.0

H-bond Acceptors 37.0

Rotatable Bonds 76.0

Heavy Atoms 172.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0375325 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/