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MYP_015307
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Basic Information
RNase 8
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
127 amino acids
C619H967N173O187S12
Standard
Sequence
KPKDMTSSQWFKTQHVQPSPQACNSAMSIINKYTERCKDLNTFLHEPFSSVAITCQTPNIACKNSCKNCHQSHGPMSLTMGELTSGKYPNCRYKEKHLNTPYIVACDPPQQGDPGYPLVPVHLDKVV
Physicochemical Analysis
14209.13 Da
8.64
4.20
3.55
0.0331
-0.63
0.56
-0.06
58.67
56.77
0.0709
12950.00
13450.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
5744.43
-65.85
197.0
209.0
455.0
991.0
29.0
142.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0089190 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Enterococcus faecium clinical isolate
7 μM
MBC
PMID16940129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16940129/
RECORD: Rec_0103708 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae ATCC 13883 0.1-0.2 0.1
0.1-0.2 μM
MBC
PMID16940129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16940129/
RECORD: Rec_0105594 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
0.2-0.9 μM
MBC
PMID16940129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16940129/
RECORD: Rec_0121484 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Enterococcus faecium DSM 2146
0.4 μM
MBC
PMID16940129 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16940129/
RECORD: Rec_0127532 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa ATCC 10145 and clincal
0.2-0.9 μM
MBC
PaperIdentification of RNase 8 as a novel human antimicrobial protein
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