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MYP_015280
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Basic Information
K22.2 (Derived from ATG16)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
RWKRHISEQLRRRDRLQRQAX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0158653 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Myristoylation
Amidation
(3-(2-naphthyl)-L-alanine) at 21; (3-(2-naphthyl)-L-alanine)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans 24h
3.2 - 6.4 μM
MIC
PMID31145591 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31145591/
RECORD: Rec_0165158 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Acylation (Arg1 conjugated with Fmoc group)
Amidation
The 'J' in the sequence is the 2-naphthyl alanine (2-Nal) residue
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa
6.4-12.8 μM
MIC
PMID31145591 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31145591/
RECORD: Rec_0167273 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
R5: Fmoc
Amidation
non-canonical residue code at 21; Fmoc, C-terminal: NH2, J: (3-(2-naphthyl)-L-alanine)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
6.4 - 12.8 μM
MIC
PMID31145591 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31145591/
RECORD: Rec_0176169 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation (Arg1 conjugated with 4-methylhexanoyl group)
Amidation
The 'J' in the sequence is the 2-naphthyl alanine (2-Nal) residue
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa
13.5-27 μM
MIC
PMID31145591 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31145591/
RECORD: Rec_0178986 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
non-canonical residue code at 21
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
4.0 - 8.0 μM
MIC
PMID31145591 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31145591/
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