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MYP_015271
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Basic Information
Teixobactin derivative 4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
11 amino acids
C63H111N15O15
Standard
Sequence
FISQIIKTKKI
Physicochemical Analysis
1318.65 Da
10.30
2.76
2.55
0.2506
0.37
0.34
0.10
11.16
141.82
0.0909
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
515.93
-2.30
18.0
18.0
48.0
93.0
1.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0090540 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
64 μg/mL
MIC
PMID30050518;28795807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0190725 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
4 μg/mL
MIC
PMID30050518;28795807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0264843 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
8 μg/mL
MIC
PMID30050518;28795807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0326230 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis ATCC 6051
2 μg/mL
MIC
PMID30050518;28795807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
RECORD: Rec_0332593 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Methylation
N-methylated phenylalanine. Small letter denote D-amino acid. Isoleucine at 5th position is allo-isoleucine. Ester bond formation between 't' and terminal 'I'.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
2 μg/mL
MIC
PMID30050518;28795807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30050518/
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