Peptide Database

Peptide NameSLAY-screened peptide P1918

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC96H142N30O33S

DescriptionStandard

        STNFPERTVWHHMSSASTNS
    

Molecular Weight2276.40 Da

Isoelectric Point (pI)6.66

Net Charge (pH 7.0)-0.36

Net Charge (pH 7.4) -0.67

Charge Density (pH 7.0) -0.0181

GRAVY Index-0.96

Hydrophobic Moment 0.44

Boman Index-0.11

Instability Index48.72

Aliphatic Index 19.50

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1027.80

LogP -15.57

H-bond Donors 37.0

H-bond Acceptors 36.0

Rotatable Bonds 69.0

Heavy Atoms 160.0

Ring Count 6.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0015260 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/