Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length286 amino acids

Chemical FormulaC1459H2271N361O409S11

DescriptionStandard

        MENVCKKVTNSVSSELQPYFQTLPVMTKIDAVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKTTLTDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMHTTGSMEVSAESDRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK
    

Molecular Weight31765.53 Da

Isoelectric Point (pI)6.06

Net Charge (pH 7.0)-3.78

Net Charge (pH 7.4) -4.49

Charge Density (pH 7.0) -0.0132

GRAVY Index0.06

Hydrophobic Moment 0.66

Boman Index0.16

Instability Index38.05

Aliphatic Index 95.03

Aromaticity 0.0979

Extinction Coeff. Reduced 14900.00

Extinction Coeff. Oxidized 14900.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0238503 VERIFIED: NO

Provenance & Taxonomy

OrganismGorilla gorilla gorilla [Animal]

FamilyBPI

Tax ID9593

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence