Peptide Database

Peptide NameSLAY-screened peptide P5615

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC113H151N25O27S

DescriptionStandard

        PHGCEHNYIPLYPFFTGAFL
    

Molecular Weight2323.62 Da

Isoelectric Point (pI)6.00

Net Charge (pH 7.0)-0.88

Net Charge (pH 7.4) -1.05

Charge Density (pH 7.0) -0.0438

GRAVY Index0.12

Hydrophobic Moment 0.18

Boman Index0.37

Instability Index18.25

Aliphatic Index 63.50

Aromaticity 0.2500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 783.09

LogP -2.93

H-bond Donors 27.0

H-bond Acceptors 29.0

Rotatable Bonds 64.0

Heavy Atoms 166.0

Ring Count 10.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0287131 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/