Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length465 amino acids

Chemical FormulaC2306H3688N610O652S18

DescriptionStandard

        MFLLKCLPLVALIAAAFSANPGVKIRLTQKGLEYGRQLGMASLLEKLKTAQIPDFSGKERVSPIGKVQYSFTNIHVVNLGLPQSSINLVPGSGVQLSISNAFISLRGNWRVKYLRFIKDSGSLDVNVNGLSISQTIAIKSDATGKPEASSAACSASVSSAKVKFHGGASWLYNLFSKFIDKALRKALEKQMCPLVAKSIADLNPHLKTLNVLAKVDKYAEIEYSMVSSPQISQPAIDLNLKGEFYNIGRHQEAPFPAPAFSLPAQSSNMIYIALSSFTPNSAGFVYNNAGVLSMYVTDDMIPRSSPIRLSTSTFGFFIPQIAQRFPGLMMKMLVKADKNPVVKFQPNVMTVDATATATAYAIQPNGTLSPLFVLNVVSQRATKRLQREKKLAISEFPQYYLSVKNVSRALDLMVFRHRFSSDDKNLVQLSKGYPLPALGKMKLVNTQLQIMQDYLMIGTDVQFTG
    

Molecular Weight50966.81 Da

Isoelectric Point (pI)9.81

Net Charge (pH 7.0)22.91

Net Charge (pH 7.4) 22.29

Charge Density (pH 7.0) 0.0493

GRAVY Index0.05

Hydrophobic Moment 0.85

Boman Index0.10

Instability Index37.51

Aliphatic Index 96.28

Aromaticity 0.0882

Extinction Coeff. Reduced 33350.00

Extinction Coeff. Oxidized 33475.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0318290 VERIFIED: NO

Provenance & Taxonomy

OrganismOryzias latipes [Plant]

FamilyBPI

Tax ID8090

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence