Peptide Database

Peptide NameEsculentin-1A

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length84 amino acids

Chemical FormulaC403H694N108O118S6

DescriptionStandard

        MFTLKKPLLLIVLLGMISLSLCEQERNADEEEGSEIKRGIFSKLAGKKLKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
    

Molecular Weight9132.86 Da

Isoelectric Point (pI)8.86

Net Charge (pH 7.0)2.49

Net Charge (pH 7.4) 2.19

Charge Density (pH 7.0) 0.0296

GRAVY Index0.13

Hydrophobic Moment 0.59

Boman Index0.06

Instability Index16.40

Aliphatic Index 118.33

Aromaticity 0.0238

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3666.02

LogP -30.54

H-bond Donors 129.0

H-bond Acceptors 127.0

Rotatable Bonds 331.0

Heavy Atoms 635.0

Ring Count 3.0

Amide Bonds 87.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0161532 VERIFIED: NO

Provenance & Taxonomy

OrganismPelophylax lessonae [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Amphibian defense peptide Non-hemolytic Non-ribosomal

RECORD: Rec_0322023 VERIFIED: NO

Provenance & Taxonomy

OrganismPelophylax lessonae [Animal]

FamilyFrog skin active peptide (FSAP)

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic Non-ribosomal

TargetGram-negative bacteria; Gram-positive bacteria

MethodQualitative functional evidence