Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length476 amino acids

Chemical FormulaC2416H3736N588O700S22

DescriptionStandard

        MWLVTIFLLMGITQIHADYPALQAVLSQKGLQKVSHWMTDWLQEELSTMKLPEVRGTVDIVLGSVYYVLHDMTVVRCDLPEPSVAFLEGTGVSLQVSGLSLAINGRWNTEFGIIHDSGWFDLAVYTINLKTILEFQSTEEHLSISTVSCSADVGGVQIHFHGGASFFFQPFVEGFSGHITEMIRERICPGIQSGIENIDKVLAGSGTVKLDPYVYLNISLTDSPVVFENGFELNVKGEFYSSSSPSEPPFSPNHFELPWTADYMLSVGMSDFCVNSAAFAYLKAGVLNITINDDMIPKASPIHLNTSQFGILIPQLPKLYPDMEMEVLLYASDTPLISFNQTMINFDLSAATKFYAIKTPNDLIPLFRLDMQYSFIAKVQIDDQLLKGVVKMQNLTISLGSTEIEKFDVAPIERMVKLAMSSFVLPKMNARLQEGLPLPRVKGFNLSNSVMTIENGFLFVATDIISPFDFLQSDKL
    

Molecular Weight52924.46 Da

Isoelectric Point (pI)4.76

Net Charge (pH 7.0)-21.60

Net Charge (pH 7.4) -22.49

Charge Density (pH 7.0) -0.0454

GRAVY Index0.21

Hydrophobic Moment 0.66

Boman Index0.20

Instability Index47.14

Aliphatic Index 100.50

Aromaticity 0.1050

Extinction Coeff. Reduced 52370.00

Extinction Coeff. Oxidized 52620.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0207668 VERIFIED: NO

Provenance & Taxonomy

OrganismAmeiurus melas (Black bullhead) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria