Peptide Database

Peptide NameSLAY-screened peptide P5057

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC86H132N24O33S2

DescriptionStandard

        TTDVEVCTSPSFASVSSHCH
    

Molecular Weight2094.24 Da

Isoelectric Point (pI)5.14

Net Charge (pH 7.0)-2.44

Net Charge (pH 7.4) -2.77

Charge Density (pH 7.0) -0.1222

GRAVY Index0.06

Hydrophobic Moment 0.20

Boman Index0.11

Instability Index83.33

Aliphatic Index 48.50

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 901.23

LogP -14.42

H-bond Donors 34.0

H-bond Acceptors 35.0

Rotatable Bonds 62.0

Heavy Atoms 145.0

Ring Count 4.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0195979 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/