Peptide Database

Peptide NameSLAY-screened peptide P492

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC84H137N35O31S2

DescriptionStandard

        RNNNNSHAIHCSNTRDLGAC
    

Molecular Weight2197.33 Da

Isoelectric Point (pI)8.09

Net Charge (pH 7.0)0.92

Net Charge (pH 7.4) 0.58

Charge Density (pH 7.0) 0.0458

GRAVY Index-1.11

Hydrophobic Moment 0.22

Boman Index-0.32

Instability Index35.32

Aliphatic Index 49.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1110.82

LogP -19.09

H-bond Donors 40.0

H-bond Acceptors 36.0

Rotatable Bonds 72.0

Heavy Atoms 152.0

Ring Count 2.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412209 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/