Peptide Database

Peptide NameDenosumab

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ RANKL inhibitor

Standard StatusStandard

Sequence Length243 amino acids

Chemical FormulaC1123H1748N296O355S10

DescriptionStandard

        EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSGITGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDPGTTVIMSWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP
    

Molecular Weight25396.31 Da

Isoelectric Point (pI)8.45

Net Charge (pH 7.0)3.03

Net Charge (pH 7.4) 2.56

Charge Density (pH 7.0) 0.0125

GRAVY Index-0.13

Hydrophobic Moment 0.49

Boman Index0.11

Instability Index47.20

Aliphatic Index 69.75

Aromaticity 0.0864

Extinction Coeff. Reduced 40910.00

Extinction Coeff. Oxidized 41285.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0305601 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Bone metabolism regulator Anti-resorptive RANKL inhibitor

Half-Life25.4 d