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MYP_014985
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Basic Information
DET4
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
10 amino acids
C47H76N12O15
Standard
Sequence
AGVKDGKLDF
Physicochemical Analysis
1049.18 Da
6.00
-0.20
-0.40
-0.0204
-0.30
0.22
0.01
-18.40
78.00
0.1000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
451.86
-3.80
15.0
15.0
36.0
74.0
1.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009695 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
Dengue virus 2(DENV2) | LLC-MK2 cells
35 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of dengue virus entry into target cells using synthetic antiviral peptides. | Alhoot MA, Rathinam AK, Wang SM, Manikam R, Sekaran SD. | Int J Med Sci. 2013 Apr 16;10(6):719-29. | DOI:10.7150/ijms.5037 | PMID:23630436 PMID23630436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23630436/
RECORD: Rec_0063785 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
dengue virus 2(DENV2):inhibition of viral replication in LLC-MK2 cells
35 μM
IC50
PaperPubMed PMID: 23630436 PMID23630436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23630436/
RECORD: Rec_0155577 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0259662 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 2 virus (Virus entry); LLC-MK2
84.6 %
Plaque assay
PaperInhibition of dengue virus entry into target cells using synthetic antiviral peptides. | Alhoot MA, Rathinam AK, Wang SM, Manikam R, Sekaran SD. | Int J Med Sci. 2013 | PMID:23630436 PMID23630436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23630436/
RECORD: Rec_0317821 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 23630436 PMID23630436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23630436/
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