Peptide Database

Peptide NameEtanercept

Function Ontology

Immunology ▸ Cytokine / receptor signaling modulation ▸ TNF-alpha inhibition

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length255 amino acids

Chemical FormulaC1150H1811N333O378S29

DescriptionStandard

        LPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDEPKSCDKTHTCPPCPAPELL
    

Molecular Weight27279.57 Da

Isoelectric Point (pI)6.55

Net Charge (pH 7.0)-1.02

Net Charge (pH 7.4) -1.89

Charge Density (pH 7.0) -0.0040

GRAVY Index-0.46

Hydrophobic Moment 0.56

Boman Index-0.05

Instability Index66.88

Aliphatic Index 46.31

Aromaticity 0.0510

Extinction Coeff. Reduced 23950.00

Extinction Coeff. Oxidized 25450.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0298416 VERIFIED: YES

Provenance & Taxonomy

OrganismCricetulus griseus [Animal]

FamilyFusion protein

Tax ID10029

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Anti-inflammatory TNF inhibitor

Half-Life103 ± 30 h