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MYP_014889
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Basic Information
Fluoromethyl ketone proteinase inhibitor
Antimicrobial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Alanine Carboxypeptidase Inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Standard
2 amino acids
C12H16N2O3
Standard
Sequence
FA
Physicochemical Analysis
236.27 Da
5.53
-0.24
-0.44
-0.1200
2.30
0.62
0.91
5.00
50.00
0.5000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
92.42
0.15
3.0
3.0
5.0
17.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0411224 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Protease/Proteasome inhibitor
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Benzyloxycarbonyl
Fluoromethyl ketone
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum Itg2
0.028 μM
IC50; Microscopy (Giemsa staining)
PMID8450035 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8450035/
RECORD: Rec_0424370 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Z=benzyloxycarbonyl
CH2F
Bio-Activity Profile
Antiparasitic Antimicrobial Antiplasmodial Cysteine protease inhibitor
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0426601 VERIFIED: NO
Provenance & Taxonomy
Theobroma cacao [Plant]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Taste
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