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MYP_014889
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Basic Information
Fluoromethyl ketone proteinase inhibitor
Antimicrobial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Alanine Carboxypeptidase Inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Standard
2 amino acids
C12H16N2O3
Standard
Sequence
FA
Physicochemical Analysis
236.27 Da
5.53
-0.24
-0.44
-0.1200
2.30
0.62
0.91
5.00
50.00
0.5000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
92.42
0.15
3.0
3.0
5.0
17.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0125457 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
487.1 μM
IC50
PaperCharacterisation of the hydrolytic specificity of Aspergillus niger derived prolyl endoproteinase on bovine β-casein and determination of ACE inhibitory activity | Norris, R. et al. | DOI: 10.1016/j.foodchem.2014.01.056 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0144914 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Protease/Proteasome inhibitor
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Benzyloxycarbonyl
Fluoromethyl ketone
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium falciparum Itg2
1.80 μM
LD50; Microscopy (Giemsa staining)
PMID1939639 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1939639/
RECORD: Rec_0149536 VERIFIED: NO
Provenance & Taxonomy
Amaranthus hypochondriacus [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory
RECORD: Rec_0207942 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Alanine Carboxypeptidase Inhibitor
PaperLevy C. C., Goldman P.. Bacterial peptidases. 3. An enzyme specific for N-acyl linkages to alanine. J. Biol. Chem., 244, 4467-4472, 1969.
RECORD: Rec_0261723 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Protease/Proteasome inhibitor
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Benzyloxycarbonyl
Fluoromethyl ketone
Bio-Activity Profile
Antimicrobial Cysteine protease inhibitor Antiparasitic Antimalarial
Plasmodium vinckei
2.2 μM
IC50; Microscopy (Giemsa staining)
PMID8450035 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8450035/
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