Peptide Database

Peptide NameEcallantide

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Standard StatusStandard

Sequence Length60 amino acids

Chemical FormulaC305H448N88O91S8

DescriptionStandard

        EAMHSFCAFKADDGPCRAAHPRWFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRD
    

Molecular Weight7059.88 Da

Isoelectric Point (pI)5.61

Net Charge (pH 7.0)-2.03

Net Charge (pH 7.4) -2.41

Charge Density (pH 7.0) -0.0338

GRAVY Index-0.71

Hydrophobic Moment 0.62

Boman Index-0.15

Instability Index60.11

Aliphatic Index 27.83

Aromaticity 0.1500

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2912.95

LogP -29.75

H-bond Donors 106.0

H-bond Acceptors 99.0

Rotatable Bonds 232.0

Heavy Atoms 492.0

Ring Count 14.0

Amide Bonds 64.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0276597 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]

FamilyEnzyme

Tax ID9606;4932

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideDisulfide-bonded therapeutic scaffold described in source text

Other ModsLipidation

Bio-Activity Profile

Function

Immunomodulatory Coagulation factor replacement

Half-LifeFollowing subcutaneous administration of 30 mg ecallantide, the mean elimination half-life was 2.0 ± 0.5 hours [FDA Label].