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MYP_014812
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Basic Information
Corticostatin-related peptide RK-1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
32 amino acids
C159H245N41O47S7
Standard
Sequence
MPCSCKKYCDPWEVIDGSCGLFNSKYICCREK
Physicochemical Analysis
3707.35 Da
7.54
0.44
0.13
0.0138
-0.34
0.44
-0.07
46.56
45.62
0.1250
8480.00
8855.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1423.05
-13.00
55.0
55.0
120.0
254.0
7.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015177 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
alpha-defensin family
9986; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-29; 5-19; 9-28
Bio-Activity Profile
Antimicrobial alpha-defensin family Antibacterial Host defense Defensin-like
PaperPDB 1EWS structural record; NMR; chain A; residues 1-32
RECORD: Rec_0027759 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Alpha-defensin; Defensin
9986
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Anti-Gram-negative Non-hemolytic
Escherichia coli
PMID8631871;11123900 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8631871/
RECORD: Rec_0073586 VERIFIED: YES
Provenance & Taxonomy
Pisum sativum [Plant]; Mammalia [Animal]
Defensin
3888; 40674
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-19; 5-28; 9-29
Bio-Activity Profile
Antimicrobial
PMID2374718 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2374718/
RECORD: Rec_0079735 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Defensin
9986
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
PMID8631871 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8631871/
RECORD: Rec_0184932 VERIFIED: YES
Provenance & Taxonomy
Oryctolagus cuniculus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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