Peptide Database

Peptide NameBig defensin (RPD-1)

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC52H74N12O16

DescriptionStandard

        AVPDVAFNAYG
    

Molecular Weight1123.21 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.20

Net Charge (pH 7.4) -1.39

Charge Density (pH 7.0) -0.1095

GRAVY Index0.57

Hydrophobic Moment 0.23

Boman Index0.40

Instability Index12.03

Aliphatic Index 80.00

Aromaticity 0.1818

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 446.15

LogP -3.70

H-bond Donors 14.0

H-bond Acceptors 15.0

Rotatable Bonds 30.0

Heavy Atoms 80.0

Ring Count 3.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0368265 VERIFIED: YES

Provenance & Taxonomy

OrganismVenerupis philippinarum [Animal]

FamilyDefensin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetBacillus subtilis

Activity76.8 μg/mL

MethodMIC

RECORD: Rec_0368683 VERIFIED: YES

Provenance & Taxonomy

OrganismVenerupis philippinarum [Animal]

FamilyDefensin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer

TargetEscherichia coli

Activity76.8 μg/mL

MethodMIC

RECORD: Rec_0379412 VERIFIED: YES

Provenance & Taxonomy

OrganismVenerupis philippinarum [Animal]

FamilyDefensin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli

Activity76.8 μg/mL

MethodMIC

RECORD: Rec_0388787 VERIFIED: YES

Provenance & Taxonomy

OrganismRuditapes philippinarum [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetV. anguillarum

RECORD: Rec_0396871 VERIFIED: YES

Provenance & Taxonomy

OrganismRuditapes philippinarum [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetBacillus subtilis

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