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MYP_014806
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Basic Information
Big defensin (RPD-1)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
11 amino acids
C52H74N12O16
Standard
Sequence
AVPDVAFNAYG
Physicochemical Analysis
1123.21 Da
4.05
-1.20
-1.39
-0.1095
0.57
0.23
0.40
12.03
80.00
0.1818
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
446.15
-3.70
14.0
15.0
30.0
80.0
3.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0360515 VERIFIED: YES
Provenance & Taxonomy
Ruditapes philippinarum [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PMID14673509 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14673509/
RECORD: Rec_0362311 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 54.5%, C 45.5% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0362660 VERIFIED: YES
Provenance & Taxonomy
Venerupis philippinarum [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperSheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Dec;35(12):1145-8. | http://www.ncbi.nlm.nih.gov/pubmed/14673509 PMID14673509 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14673509/
RECORD: Rec_0363450 VERIFIED: YES
Provenance & Taxonomy
Venerupis philippinarum [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Vibrio anguillarum
19.2 μg/mL
MIC
PMID14673509 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14673509/
RECORD: Rec_0363771 VERIFIED: YES
Provenance & Taxonomy
Ruditapes philippinarum [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Antifungal Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Escherichia coli
PMID14673509 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14673509/
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