Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length465 amino acids

Chemical FormulaC2285H3661N593O665S17

DescriptionStandard

        MSLRVWLLLVVVVPVTLGTNPGVKVRLTQKGLEYGRQLGISSIQQKLRTIKVPDISGKQKVSPIGKVEYSLSNMNIVDVGLPKSAVTPVAGTGIKLSIGDAFIHLHGNWRVKYLRVIKDSGSFDLSVNALAISTSIAIHSDETGRPTVSSVSCEAHVGSVSVKFHGGASWLYNLFTNFIDKALRNTLEKQICPLVADAVSDMNPHLKTLNVIAKVDKYTEIEYSMVTSPTVSESSIDLSLKGEFYSIGKHQEAPFSPVAFFLPPQANNMLYFGISAYTPNTAAFAYNSAGALSLYITDDMIPQSSPIRLNTKTFGTFIPQIAKRYPGLMMKLLLQTIKTPNISFQPNNVTIQASATVTAYAIQPNTTLTPLFVLNLNTSVSGKMFVSEMRLAGAVTLNEMDLTLRTSYIGDFQVRCGINLSEVNAIMKLSQGYPLPAIGKMKLVNTQVQVLKDYMLVGTDVQFTG
    

Molecular Weight50625.19 Da

Isoelectric Point (pI)9.34

Net Charge (pH 7.0)11.09

Net Charge (pH 7.4) 10.38

Charge Density (pH 7.0) 0.0239

GRAVY Index0.14

Hydrophobic Moment 0.78

Boman Index0.15

Instability Index28.17

Aliphatic Index 101.20

Aromaticity 0.0796

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40465.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0097128 VERIFIED: NO

Provenance & Taxonomy

OrganismCynoglossus semilaevis [Bacterium]

FamilyBPI

Tax ID244447

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence