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MYP_014720
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Basic Information
TP1[Y8A] (Derived from TP1)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
17 amino acids
C93H150N34O19S4
Standard
Sequence
KWCFRVCARGICYRRCR
Physicochemical Analysis
2176.66 Da
10.16
5.72
5.45
0.3364
-0.34
0.64
-0.42
23.17
45.88
0.1765
6990.00
7240.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
900.46
-7.41
40.0
29.0
70.0
150.0
4.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0283410 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii BAA
0.5 μg/mL
MIC
PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0283989 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus ATCC 43300 (MRSA)
4 μg/mL
MIC
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0321288 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa FADDIFA070 (PmxR)
MIC
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0321747 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)
0.125 μg/mL
MIC
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0356147 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Klebsiella pneumoniae BAA 2146 (NDM-1 pos)
8 μg/mL
MIC
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
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