Peptide Database

Peptide NameFp8

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length44 amino acids

Chemical FormulaC211H351N57O74

DescriptionStandard

        VDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE
    

Molecular Weight4870.38 Da

Isoelectric Point (pI)4.32

Net Charge (pH 7.0)-5.25

Net Charge (pH 7.4) -5.48

Charge Density (pH 7.0) -0.1192

GRAVY Index-0.26

Hydrophobic Moment 0.70

Boman Index0.00

Instability Index29.60

Aliphatic Index 128.41

Aromaticity 0.0227

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2172.83

LogP -21.98

H-bond Donors 71.0

H-bond Acceptors 69.0

Rotatable Bonds 173.0

Heavy Atoms 342.0

Ring Count 1.0

Amide Bonds 50.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0287596 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV Fusion inhibition

TargetSARS-CoV

Activity>50 μM

MethodEC50

Half-LifeMammalian: 100 h; Yeast: >20 h; E. coli: >10 h

PaperSevere acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. | Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ. | Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8455-60. | DOI:10.1073/pnas.0400576101 | PMID:15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/

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