Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length68 amino acids

Chemical FormulaC342H565N97O92S3

DescriptionStandard

        MVWMVTVVLLFLSSHTLGTNPALKVRVTQKALDYGRQLGMQALQAELKKINIPELSGKSGRVRYRFSG
    

Molecular Weight7603.93 Da

Isoelectric Point (pI)10.67

Net Charge (pH 7.0)6.59

Net Charge (pH 7.4) 6.31

Charge Density (pH 7.0) 0.0969

GRAVY Index0.03

Hydrophobic Moment 0.70

Boman Index0.05

Instability Index14.43

Aliphatic Index 104.56

Aromaticity 0.0735

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3072.48

LogP -27.30

H-bond Donors 109.0

H-bond Acceptors 103.0

Rotatable Bonds 258.0

Heavy Atoms 534.0

Ring Count 9.0

Amide Bonds 73.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0031321 VERIFIED: NO

Provenance & Taxonomy

OrganismCallorhinchus milii [Animal]

FamilyBPI

Tax ID7868

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence