Peptide Database

Peptide NameSLAY-screened peptide P2416

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H158N28O29

DescriptionStandard

        VLLTHAATFPESDVHVRLPN
    

Molecular Weight2216.49 Da

Isoelectric Point (pI)5.99

Net Charge (pH 7.0)-1.09

Net Charge (pH 7.4) -1.40

Charge Density (pH 7.0) -0.0544

GRAVY Index0.18

Hydrophobic Moment 0.31

Boman Index0.15

Instability Index53.25

Aliphatic Index 112.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 896.28

LogP -7.83

H-bond Donors 30.0

H-bond Acceptors 30.0

Rotatable Bonds 66.0

Heavy Atoms 157.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0254482 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/