Peptide Database

Peptide NamePB1 (1-25)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC129H201N29O37S

DescriptionStandard

        MDVNPTLLFLKVPAQNAISTTFPYT
    

Molecular Weight2782.21 Da

Isoelectric Point (pI)5.59

Net Charge (pH 7.0)-0.50

Net Charge (pH 7.4) -0.72

Charge Density (pH 7.0) -0.0200

GRAVY Index0.31

Hydrophobic Moment 0.29

Boman Index0.26

Instability Index26.31

Aliphatic Index 93.60

Aromaticity 0.1200

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1049.32

LogP -8.59

H-bond Donors 34.0

H-bond Acceptors 38.0

Rotatable Bonds 83.0

Heavy Atoms 196.0

Ring Count 6.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0347922 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetInfluenza A(FluA):inhibition of PA-binding activity and virus replication

Activity0.0018±0.00049 μM

MethodIC50

RECORD: Rec_0412560 VERIFIED: YES

Provenance & Taxonomy

OrganismInfluenza A virus [Virus]

FamilyVirus-derived peptide

Tax ID11320;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Replication inhibitor

TargetInfluenza A virus (Replication); MDCK

Activity0.0018 μM

MethodELISA

PaperIdentification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. | Wunderlich K, Mayer D, Ranadheera C, Holler AS, Manz B, Martin A, Chase G, Tegge W, Frank R, Kessler U, Schwemmle M. | PLoS One. 2009 | PMID:19841738 PMID19841738 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19841738/

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