Peptide Database

Peptide Name[R15A, R16A]GeXIVA[1,2]

Function Ontology

Anticancer

Antimicrobial

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC133H217N49O41S4

DescriptionStandard

        TCRSSGRYCRSPYDAARRYCRRITDACV
    

Molecular Weight3286.71 Da

Isoelectric Point (pI)9.57

Net Charge (pH 7.0)4.36

Net Charge (pH 7.4) 4.10

Charge Density (pH 7.0) 0.1556

GRAVY Index-0.86

Hydrophobic Moment 0.87

Boman Index-0.47

Instability Index120.59

Aliphatic Index 35.00

Aromaticity 0.1071

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4720.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1509.97

LogP -20.52

H-bond Donors 63.0

H-bond Acceptors 50.0

Rotatable Bonds 104.0

Heavy Atoms 227.0

Ring Count 4.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0283393 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyConotoxin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anticancer

RECORD: Rec_0432067 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyconotoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

α9α10 nicotinic acetylcholine receptor antagonist Ion-channel inhibitor

Targetrat α9α10 nicotinic acetylcholine receptor (rα9α10 nAChR)

Activity260 nM

MethodIC50 (two-electrode voltage-clamp electrophysiology)