Peptide Database

Peptide NameP7(DENV-2 gp (662-674))

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC76H119N19O18

DescriptionStandard

        VEPGQLKLNWFKK
    

Molecular Weight1586.87 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)1.73

Net Charge (pH 7.4) 1.52

Charge Density (pH 7.0) 0.1334

GRAVY Index-0.81

Hydrophobic Moment 0.30

Boman Index-0.08

Instability Index-8.55

Aliphatic Index 82.31

Aromaticity 0.1538

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 621.06

LogP -2.54

H-bond Donors 20.0

H-bond Acceptors 20.0

Rotatable Bonds 53.0

Heavy Atoms 113.0

Ring Count 4.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0326956 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-DENV Entry inhibition

TargetDENV-2 (dengue virus serotype 2) | endothelial cells

Activity12.86±5.96 μM

MethodIC50

Half-LifeMammalian: 100 h; Yeast: >20 h; E. coli: >10 h

PaperPeptides P4 and P7 derived from E protein inhibit entry of dengue virus serotype 2 via interacting with β3 integrin. | Cui X, Wu Y, Fan D, Gao N, Ming Y, Wang P, An J. | Antiviral Res. 2018 Jul;155:20-27. | DOI:10.1016/j.antiviral.2018.04.018 | PMID:29709564 PMID29709564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29709564/

RECORD: Rec_0369479 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetDENV-2

Activity40-50 % Inhibition

MethodInhibition

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