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MYP_014348
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Basic Information
P7(DENV-2 gp (662-674))
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C76H119N19O18
Standard
Sequence
VEPGQLKLNWFKK
Physicochemical Analysis
1586.87 Da
9.70
1.73
1.52
0.1334
-0.81
0.30
-0.08
-8.55
82.31
0.1538
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
621.06
-2.54
20.0
20.0
53.0
113.0
4.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023182 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
xic effect on HUVEC(Human umbilical vein endothelial cells) at concentrations up to 100 μM
100 μM
Cytotoxicity
PMID29709564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29709564/
RECORD: Rec_0062400 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
DENV-2(dengue virus serotype 2):inhibition of virus entry in HUVECs(human umbilical vein endothelial cells)(65 ± 6% inhibition at 40 μM,55± 12% inhibition at 20 μM,41± 13% inhibition at 10 μM
12.86±5.96 μM
IC50
PMID29709564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29709564/
RECORD: Rec_0105605 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID29709564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29709564/
RECORD: Rec_0169372 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
DENV-1 (dengue virus serotype 1) | endothelial cells
40 μM
% inhibition
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperPeptides P4 and P7 derived from E protein inhibit entry of dengue virus serotype 2 via interacting with β3 integrin. | Cui X, Wu Y, Fan D, Gao N, Ming Y, Wang P, An J. | Antiviral Res. 2018 Jul;155:20-27. | DOI:10.1016/j.antiviral.2018.04.018 | PMID:29709564 PMID29709564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29709564/
RECORD: Rec_0183521 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-1
60-70 % Inhibition
Inhibition
PMID29709564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29709564/
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