Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length518 amino acids

Chemical FormulaC2549H4042N664O727S17

DescriptionStandard

        MSKARNLLLASLLLCLHYSPLSGATGPGFVGRITDKGLDYARQEGVAALQQKLAQLTLPDFSGSFRVKVIGRVDYKLYSLNIRSFQLPSSAIAPVPGTGLKVSITNAFAEVTGDWLVKKRWFKDHGSFDLKVEGISISVGLKLGADASGRPTVGTADCAAHISDVKVHFSGRLSWLYNLFHKNIESSFRNTMEGKVCEEVSSSIGSKLQPFLQTLPVTARIDKVSGIDYSLVAPPVASQNSLDLDLKGEFFSLAHRSAPPFTPPALAFPVDHDRMLYFGISTYFFNTAGLVYYGAGEMNFFITDDMVPKEFKVRLNTTCFKPFVPQLEKLYPNMLMKLQVSPSSAPSLTITPDAISLSPAVDIRAFAILPNASLASLFVIGASTTMSAKVSVNSTKIFGSLKLGKLQLSLKHSDVGPFSVQLMEAIMNYLASSTLLPAMNARLAEGFPLPLPDHVELSSAFLQLRQVGDALALSQKKLWVLREASCILRLKTNCGESSLKEQVEPTLRQPSLGPAGIP
    

Molecular Weight56166.48 Da

Isoelectric Point (pI)9.16

Net Charge (pH 7.0)10.26

Net Charge (pH 7.4) 9.39

Charge Density (pH 7.0) 0.0198

GRAVY Index0.12

Hydrophobic Moment 0.72

Boman Index0.13

Instability Index38.96

Aliphatic Index 97.92

Aromaticity 0.0869

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40255.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0099107 VERIFIED: YES

Provenance & Taxonomy

OrganismPodarcis muralis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria